Name | N-[(9-Ethyl-9H-carbazol-3-yl)methyl]-1,2,3,4-tetrahydro-1-naphthalenamine |
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Synonyms |
N-[(9-Ethyl-9H-carbazol-3-yl)methyl]-1,2,3,4-tetrahydro-1-naphthalenamine
9H-Carbazole-3-methanamine, 9-ethyl-N-(1,2,3,4-tetrahydro-1-naphthalenyl)- (9-Ethyl-9H-carbazol-3-ylmethyl)-(1,2,3,4-tetrahydro-naphthalen-1-yl)-amine |
Description | PJ-68 is a potent, selective inhibitor of arginine methyltransferase PRMT5 with IC50 of 517 nM, shows no inhibitory activity against type I PRMT family members ( (PRMT1, 3, 4, 6, and 8); markedly decreases BCR-ABL mRNA levels in both CD34+CD38-cells and CD34+CD38+ cells, reduces survival and self-renewal capacity of CML CD34+ cells, increases p15INK4B and p27KIP1 but not p16INK4A and p57KIP2 expression; reduces growth of CML LSCs and prolongs survival of CML mice. |
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References | References 1. Jin Y, et al. J Clin Invest. 2016 Oct 3;126(10):3961-3980. 2. Kaushik S, et al. Leukemia. 2018 Feb;32(2):499-509. View Related Products by Target Histone Methyltransferase (HMTase) |
Density | 1.2±0.1 g/cm3 |
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Boiling Point | 553.4±42.0 °C at 760 mmHg |
Molecular Formula | C25H26N2 |
Molecular Weight | 354.487 |
Flash Point | 288.5±27.9 °C |
Exact Mass | 354.209595 |
LogP | 6.68 |
Vapour Pressure | 0.0±1.5 mmHg at 25°C |
Index of Refraction | 1.649 |