310460-39-0
310460-39-0 structure
- Name: CPYPP
- Chemical Name: (4Z)-4-[(2E)-3-(2-Chlorophenyl)-2-propen-1-ylidene]-1-phenyl-3,5-pyrazolidinedione
- CAS Number: 310460-39-0
- Molecular Formula: C18H13ClN2O2
- Molecular Weight: 324.761
- Catalog: Research Areas Inflammation/Immunology
- Create Date: 2020-01-19 21:38:55
- Modify Date: 2025-08-26 16:30:31
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CPYPP is a small-molecule inhibitor of the Rac activator DOCK2 with IC50 of 22.8 uM (DOCK2DHR-2-mediated Rac GEF activity), inhibits DOCK2-Rac1 interaction; binds to DOCK2 DHR-2 domain in a reversible manner and inhibited its catalytic activity in vitro; blocks both chemokine receptor- and antigen receptor-mediated Rac activation in lymphocytes, resulting in marked reduction of chemotactic response and T cell activation.
| Name | (4Z)-4-[(2E)-3-(2-Chlorophenyl)-2-propen-1-ylidene]-1-phenyl-3,5-pyrazolidinedione |
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| Synonyms |
(4Z)-4-[(2E)-3-(2-Chlorophenyl)-2-propen-1-ylidene]-1-phenyl-3,5-pyrazolidinedione
3,5-Pyrazolidinedione, 4-[(2E)-3-(2-chlorophenyl)-2-propen-1-ylidene]-1-phenyl-, (4Z)- |
| Description | CPYPP is a small-molecule inhibitor of the Rac activator DOCK2 with IC50 of 22.8 uM (DOCK2DHR-2-mediated Rac GEF activity), inhibits DOCK2-Rac1 interaction; binds to DOCK2 DHR-2 domain in a reversible manner and inhibited its catalytic activity in vitro; blocks both chemokine receptor- and antigen receptor-mediated Rac activation in lymphocytes, resulting in marked reduction of chemotactic response and T cell activation. |
|---|---|
| References | References 1. Nishikimi A, et al. Chem Biol. 2012 Apr 20;19(4):488-97. 2. Watanabe M, et al. J Immunol. 2014 Dec 1;193(11):5660-7. View Related Products by Target Small GTPase |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C18H13ClN2O2 |
| Molecular Weight | 324.761 |
| Exact Mass | 324.066559 |
| LogP | 3.35 |
| Index of Refraction | 1.728 |
| Hazard Codes | Xi |
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