2101206-36-2
2101206-36-2 structure
- Name: EML-631
- Chemical Name: (2-{[4-(1-Pyrrolidinylmethoxy)phenyl]amino}-1,4-phenylene)bis({4-[2-(1-pyrrolidinyl)ethyl]-1-piperidinyl}methanone)
- CAS Number: 2101206-36-2
- Molecular Formula: C41H60N6O3
- Molecular Weight: 684.953
- Create Date: 2020-01-20 17:06:56
- Modify Date: 2024-01-19 10:36:11
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A small-molecule inhibitor of Spindlin1 (SPIN1) with Kd of 4 uM; shows increased selectivity and engages SPIN1 in cells, block its ability to 'read' H3K4me3 marks and inhibit its transcriptional-coactivator activity.
| Name | (2-{[4-(1-Pyrrolidinylmethoxy)phenyl]amino}-1,4-phenylene)bis({4-[2-(1-pyrrolidinyl)ethyl]-1-piperidinyl}methanone) |
|---|---|
| Synonyms |
(2-{[4-(1-Pyrrolidinylmethoxy)phenyl]amino}-1,4-phenylene)bis({4-[2-(1-pyrrolidinyl)ethyl]-1-piperidinyl}methanone)
Methanone, 1,1'-[2-[[4-(1-pyrrolidinylmethoxy)phenyl]amino]-1,4-phenylene]bis[1-[4-[2-(1-pyrrolidinyl)ethyl]-1-piperidinyl]- |
| Description | A small-molecule inhibitor of Spindlin1 (SPIN1) with Kd of 4 uM; shows increased selectivity and engages SPIN1 in cells, block its ability to 'read' H3K4me3 marks and inhibit its transcriptional-coactivator activity. |
|---|---|
| References | References 1. Bae N, et al. Nat Chem Biol. 2017 May 15. doi: 10.1038/nchembio.2377. 2. Wang W, et al. EMBO Rep. 2011 Oct 28;12(11):1160-6. View Related Products by Target Other Targets |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 821.3±65.0 °C at 760 mmHg |
| Molecular Formula | C41H60N6O3 |
| Molecular Weight | 684.953 |
| Flash Point | 450.5±34.3 °C |
| Exact Mass | 684.472717 |
| LogP | 4.49 |
| Vapour Pressure | 0.0±3.0 mmHg at 25°C |
| Index of Refraction | 1.594 |