2007923-17-1

2007923-17-1 structure

Name: Nacubactam
Chemical Name: (2S,5R)-N-(2-Aminoethoxy)-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide hydrate (1:1)
CAS Number: 2007923-17-1
Molecular Formula: C₉H₁₈N₄O₈S
Molecular Weight: 342.326
Create Date: 2020-01-20 11:44:56
Modify Date: 2025-08-26 00:25:46
Nacubactam (OP 0595, RG 6080, RO 7079901) is a diazabicyclooctane that inhibits class A and C β-lactamases with IC50 of <1 uM, also acts as a PBP2-active antibacterial; exhibits MICs of 0.5 to 4 μg/ml for most members of the family Enterobacteriaceae, owing to inhibition of PBP2; has MICs of 1-4 mg/ml for Escherichia coli, Enterobacter, Citrobacter and Klebsiella spp; increases the antibacterial activity of cefepime in both in vitro and in vivo. Bacterial Infection Phase 1 Clinical

Name	(2S,5R)-N-(2-Aminoethoxy)-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide hydrate (1:1)
Synonyms	1,6-Diazabicyclo[3.2.1]octane-2-carboxamide, N-(2-aminoethoxy)-7-oxo-6-(sulfooxy)-, (2S,5R)-, hydrate (1:1) (2S,5R)-N-(2-Aminoethoxy)-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide hydrate (1:1)

Description	Nacubactam (OP 0595, RG 6080, RO 7079901) is a diazabicyclooctane that inhibits class A and C β-lactamases with IC50 of <1 uM, also acts as a PBP2-active antibacterial; exhibits MICs of 0.5 to 4 μg/ml for most members of the family Enterobacteriaceae, owing to inhibition of PBP2; has MICs of 1-4 mg/ml for Escherichia coli, Enterobacter, Citrobacter and Klebsiella spp; increases the antibacterial activity of cefepime in both in vitro and in vivo. Bacterial Infection Phase 1 Clinical
References	References 1. Morinaka A, et al. J Antimicrob Chemother. 2015 Oct;70(10):2779-86. 2. Livermore DM, et al. J Antimicrob Chemother. 2015 Nov;70(11):3032-41. 3. Livermore DM, et al. Antimicrob Agents Chemother. 2015 Nov 9;60(1):554-60. 4. Morinaka A, et al. J Antibiot (Tokyo). 2017 Mar;70(3):246-250. View Related Products by Target Bacterial Bacterial Infection