Name | 4-({5-[3-(2-Chloro-4-methylphenyl)-4-pyridinyl]-1,3-thiazol-2-yl}amino)phenol |
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Synonyms |
Phenol, 4-[[5-[3-(2-chloro-4-methylphenyl)-4-pyridinyl]-2-thiazolyl]amino]-
4-({5-[3-(2-Chloro-4-methylphenyl)-4-pyridinyl]-1,3-thiazol-2-yl}amino)phenol |
Description | A novel potent LIMK inhibitor with IC50 of 0.3 nM and 1 nM for LIMK1 and LIMK2, respectively; inhibits cofilin phosphorylation and increase αTubulin acetylation in cells; shows significant sensitivity against 656 cancer cell lines, and rhabdomyosarcoma, neuroblastoma and kidney cancer cells (mean EC50=19.2 uM). |
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References | References 1. Mardilovich K, et al. Oncotarget. 2015 Nov 17;6(36):38469-86. 2. Charles MD, et al. J Med Chem. 2015 Oct 22;58(20):8309-13. View Related Products by Target LIM Kinase (LIMK) |
Density | 1.4±0.1 g/cm3 |
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Boiling Point | 556.6±60.0 °C at 760 mmHg |
Molecular Formula | C21H16ClN3OS |
Molecular Weight | 393.889 |
Flash Point | 290.4±32.9 °C |
Exact Mass | 393.070251 |
LogP | 4.37 |
Vapour Pressure | 0.0±1.6 mmHg at 25°C |
Index of Refraction | 1.695 |