1537150-15-4
1537150-15-4 structure
- Name: SMN2 modulator 27
- Chemical Name: 3-Chloro-4-fluoro-N-[5-(1-hydroxycyclobutyl)-1,3-thiazol-2-yl]benzamide
- CAS Number: 1537150-15-4
- Molecular Formula: C14H12ClFN2O2S
- Molecular Weight: 326.774
- Create Date: 2020-01-11 13:03:36
- Modify Date: 2023-02-15 10:35:54
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SMN2 modulator 27 is a novel SMN2 modulator that stabilize the SMN protein with EC50 of 0.29 uM; shows excellent in vitro properties and a promising mouse PK profile, stabilizes the SMN protein, unrelated to global proteasome or autophagy inhibition; a novel therapeutic mechanism that should complement other modalities for treatment of SMA.
| Name | 3-Chloro-4-fluoro-N-[5-(1-hydroxycyclobutyl)-1,3-thiazol-2-yl]benzamide |
|---|---|
| Synonyms |
3-Chloro-4-fluoro-N-[5-(1-hydroxycyclobutyl)-1,3-thiazol-2-yl]benzamide
Benzamide, 3-chloro-4-fluoro-N-[5-(1-hydroxycyclobutyl)-2-thiazolyl]- |
| Description | SMN2 modulator 27 is a novel SMN2 modulator that stabilize the SMN protein with EC50 of 0.29 uM; shows excellent in vitro properties and a promising mouse PK profile, stabilizes the SMN protein, unrelated to global proteasome or autophagy inhibition; a novel therapeutic mechanism that should complement other modalities for treatment of SMA. |
|---|---|
| References | References 1. Rietz A, et al. J Med Chem. 2017 Jun 8;60(11):4594-4610. View Related Products by Target SMN2 Modulator |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Molecular Formula | C14H12ClFN2O2S |
| Molecular Weight | 326.774 |
| Exact Mass | 326.029205 |
| LogP | 3.27 |
| Index of Refraction | 1.698 |