1424605-11-7
1424605-11-7 structure
- Name: LRE1
- Chemical Name: 6-Chloro-N4-cyclopropyl-N4-(3-thienylmethyl)-2,4-pyrimidinediamine
- CAS Number: 1424605-11-7
- Molecular Formula: C12H13ClN4S
- Molecular Weight: 280.776
- Create Date: 2020-01-11 22:44:50
- Modify Date: 2023-01-11 18:31:14
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A novel potent, specific and allosteric soluble adenylyl cyclase (sAC) inhibitor with IC50 of 3.3 uM in RF-MSS assays; does not inhibit other transmembrane adenylyl cyclases (tmACs) indluding tmACs I, II, V, VIII and IX at 50 uM; binds to the bicarbonate activator binding site and inhibited sAC via a unique allosteric mechanism; inhibits cAMP accumulation in 4-4 cells with an IC50 of 11 uM, and is non-toxic and does not uncouple mitochondria.
| Name | 6-Chloro-N4-cyclopropyl-N4-(3-thienylmethyl)-2,4-pyrimidinediamine |
|---|---|
| Synonyms |
MFCD23150321
6-Chloro-N4-cyclopropyl-N4-(3-thienylmethyl)-2,4-pyrimidinediamine 2,4-Pyrimidinediamine, 6-chloro-N4-cyclopropyl-N4-(3-thienylmethyl)- |
| Description | A novel potent, specific and allosteric soluble adenylyl cyclase (sAC) inhibitor with IC50 of 3.3 uM in RF-MSS assays; does not inhibit other transmembrane adenylyl cyclases (tmACs) indluding tmACs I, II, V, VIII and IX at 50 uM; binds to the bicarbonate activator binding site and inhibited sAC via a unique allosteric mechanism; inhibits cAMP accumulation in 4-4 cells with an IC50 of 11 uM, and is non-toxic and does not uncouple mitochondria. |
|---|---|
| References | References 1. Ramos-Espiritu L, et al. Nat Chem Biol. 2016 Oct;12(10):838-44. View Related Products by Target Adenylate Cyclase |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 532.6±60.0 °C at 760 mmHg |
| Molecular Formula | C12H13ClN4S |
| Molecular Weight | 280.776 |
| Flash Point | 275.9±32.9 °C |
| Exact Mass | 280.054932 |
| LogP | 3.79 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.744 |