1247000-76-5
1247000-76-5 structure
- Name: CFI-400437
- Chemical Name: (3Z)-5-Methoxy-3-[(3-{(E)-2-[6-(4-methyl-1-piperazinyl)-3-pyridinyl]vinyl}-1H-indazol-6-yl)methylene]-1,3-dihydro-2H-indol-2-one dihydrochloride
- CAS Number: 1247000-76-5
- Molecular Formula: C29H28N6O2.2HCl
- Molecular Weight: 565.494
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Polo-like Kinase (PLK)
- Create Date: 2020-01-20 11:02:56
- Modify Date: 2025-09-10 20:21:39
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CFI-400437 is potent against PLK4 (IC50 = 0.6 nM) and selective against other members of the PLK family (>10 uM).
| Name | (3Z)-5-Methoxy-3-[(3-{(E)-2-[6-(4-methyl-1-piperazinyl)-3-pyridinyl]vinyl}-1H-indazol-6-yl)methylene]-1,3-dihydro-2H-indol-2-one dihydrochloride |
|---|---|
| Synonyms |
2H-Indol-2-one, 1,3-dihydro-5-methoxy-3-[[3-[(E)-2-[6-(4-methyl-1-piperazinyl)-3-pyridinyl]ethenyl]-1H-indazol-6-yl]methylene]-, (3Z)-, hydrochloride (1:2)
(3Z)-5-Methoxy-3-[(3-{(E)-2-[6-(4-methyl-1-piperazinyl)-3-pyridinyl]vinyl}-1H-indazol-6-yl)methylene]-1,3-dihydro-2H-indol-2-one dihydrochloride |
| Description | CFI-400437 is potent against PLK4 (IC50 = 0.6 nM) and selective against other members of the PLK family (>10 uM). |
|---|---|
| In Vitro | CFI-400437 is potent against PLK4 (IC50 = 0.6 nM) and selective against other members of the PLK family (>10 uM). Against a broad panel of kinases, only a small subset is significantly inhibited. CFI-400437 is a potent inhibitor of MCF-7, MDA-MB-468, and MDA-MB-231 cell growth and very effective in a mouse xenograft model of tumor growth. |
| Molecular Formula | C29H28N6O2.2HCl |
|---|---|
| Molecular Weight | 565.494 |
| Exact Mass | 564.180725 |