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1115899-15-4

1115899-15-4 structure
1115899-15-4 structure
  • Name: F3406
  • Chemical Name: N-(3,5-Difluorophenyl)-2-[5,7-dioxo-6-propyl-2-(1-pyrrolidinyl)-6,7-dihydro[1,3]thiazolo[4,5-d]pyrimidin-4(5H)-yl]acetamide
  • CAS Number: 1115899-15-4
  • Molecular Formula: C20H21F2N5O3S
  • Molecular Weight: 449.474
  • Create Date: 2020-01-12 00:22:50
  • Modify Date: 2025-10-06 10:42:51
  • A novel small-molecule arenaviruse inhibitor that exhibits strong anti-LCMV activity (IC50<1 uM) without cell toxicity; inhibits LCMV cell entry by specifically interfering with the pH-dependent fusion in the endosome compartment that is mediated by LCMV glycoprotein GP2; inhibits LCMV multiplication with IC50 of 0.4, 0.7 and 0.9 uM in A549 BHK-21 and Vero cells, respectively.

Name N-(3,5-Difluorophenyl)-2-[5,7-dioxo-6-propyl-2-(1-pyrrolidinyl)-6,7-dihydro[1,3]thiazolo[4,5-d]pyrimidin-4(5H)-yl]acetamide
Synonyms N-(3,5-Difluorophenyl)-2-[5,7-dioxo-6-propyl-2-(1-pyrrolidinyl)-6,7-dihydro[1,3]thiazolo[4,5-d]pyrimidin-4(5H)-yl]acetamide
Thiazolo[4,5-d]pyrimidine-4(5H)-acetamide, N-(3,5-difluorophenyl)-6,7-dihydro-5,7-dioxo-6-propyl-2-(1-pyrrolidinyl)-
Description A novel small-molecule arenaviruse inhibitor that exhibits strong anti-LCMV activity (IC50<1 uM) without cell toxicity; inhibits LCMV cell entry by specifically interfering with the pH-dependent fusion in the endosome compartment that is mediated by LCMV glycoprotein GP2; inhibits LCMV multiplication with IC50 of 0.4, 0.7 and 0.9 uM in A549 BHK-21 and Vero cells, respectively.
References References 1. Ngo N, et al. J Virol. 2015 Nov;89(21):10924-33. View Related Products by Target Arenavirus
Density 1.5±0.1 g/cm3
Molecular Formula C20H21F2N5O3S
Molecular Weight 449.474
Exact Mass 449.133301
LogP 4.18
Index of Refraction 1.631
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