Name | N-(3,5-Difluorophenyl)-2-[5,7-dioxo-6-propyl-2-(1-pyrrolidinyl)-6,7-dihydro[1,3]thiazolo[4,5-d]pyrimidin-4(5H)-yl]acetamide |
---|---|
Synonyms |
N-(3,5-Difluorophenyl)-2-[5,7-dioxo-6-propyl-2-(1-pyrrolidinyl)-6,7-dihydro[1,3]thiazolo[4,5-d]pyrimidin-4(5H)-yl]acetamide
Thiazolo[4,5-d]pyrimidine-4(5H)-acetamide, N-(3,5-difluorophenyl)-6,7-dihydro-5,7-dioxo-6-propyl-2-(1-pyrrolidinyl)- |
Description | A novel small-molecule arenaviruse inhibitor that exhibits strong anti-LCMV activity (IC50<1 uM) without cell toxicity; inhibits LCMV cell entry by specifically interfering with the pH-dependent fusion in the endosome compartment that is mediated by LCMV glycoprotein GP2; inhibits LCMV multiplication with IC50 of 0.4, 0.7 and 0.9 uM in A549 BHK-21 and Vero cells, respectively. |
---|---|
References | References 1. Ngo N, et al. J Virol. 2015 Nov;89(21):10924-33. View Related Products by Target Arenavirus |
Density | 1.5±0.1 g/cm3 |
---|---|
Molecular Formula | C20H21F2N5O3S |
Molecular Weight | 449.474 |
Exact Mass | 449.133301 |
LogP | 4.18 |
Index of Refraction | 1.631 |