1035450-90-8
1035450-90-8 structure
- Name: LCS-1.28
- Chemical Name: 4,5-Dibromo-2-(3-methylphenyl)-3(2H)-pyridazinone
- CAS Number: 1035450-90-8
- Molecular Formula: C11H8Br2N2O
- Molecular Weight: 344.002
- Create Date: 2020-01-11 22:16:41
- Modify Date: 2023-01-14 16:55:46
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LCS-1.28 is a small molecule that inhibits growth of human lung adenocarcinoma cells harboring mutations in EGFR or KRAS with IC50 of 0.05-1.6 uM; superoxide dismutase 1 (SOD1) are the most likely target of LCS-1, LCS-1.28 inhibits SOD1 in a dose-dependent manner with IC50 of 0.95 uM.
| Name | 4,5-Dibromo-2-(3-methylphenyl)-3(2H)-pyridazinone |
|---|---|
| Synonyms |
4,5-Dibromo-2-(3-methylphenyl)-3(2H)-pyridazinone
3(2H)-Pyridazinone, 4,5-dibromo-2-(3-methylphenyl)- MFCD12079180 |
| Description | LCS-1.28 is a small molecule that inhibits growth of human lung adenocarcinoma cells harboring mutations in EGFR or KRAS with IC50 of 0.05-1.6 uM; superoxide dismutase 1 (SOD1) are the most likely target of LCS-1, LCS-1.28 inhibits SOD1 in a dose-dependent manner with IC50 of 0.95 uM. |
|---|---|
| References | References 1. Somwar R, et al. J Biomol Screen. 2009 Dec;14(10):1176-84. 2. Somwar R, et al. Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16375-80. View Related Products by Target Other Targets |
| Density | 1.8±0.1 g/cm3 |
|---|---|
| Boiling Point | 371.2±52.0 °C at 760 mmHg |
| Molecular Formula | C11H8Br2N2O |
| Molecular Weight | 344.002 |
| Flash Point | 178.3±30.7 °C |
| Exact Mass | 341.900330 |
| LogP | 2.56 |
| Vapour Pressure | 0.0±0.8 mmHg at 25°C |
| Index of Refraction | 1.671 |