1034978-04-5
1034978-04-5 structure
- Name: AZD 9164
- Chemical Name: (3R)-1-[2-(4-Fluorophenyl)ethyl]-3-{[(2S)-2-phenyl-2-(1-piperidinyl)propanoyl]oxy}-1-azoniabicyclo[2.2.2]octane
- CAS Number: 1034978-04-5
- Molecular Formula: C29H38FN2O2+
- Molecular Weight: 465.622
- Create Date: 2020-01-20 10:44:57
- Modify Date: 2024-01-29 12:37:23
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A novel highly potent, selective, long acting muscarinic receptor M3 antagonist with pIC50 of 9.8, 10-fold selectivity over M2 (pIC50=9.0); demonstrates potential as a treatment for COPD. COPD Phase 2 Discontinued
| Name | (3R)-1-[2-(4-Fluorophenyl)ethyl]-3-{[(2S)-2-phenyl-2-(1-piperidinyl)propanoyl]oxy}-1-azoniabicyclo[2.2.2]octane |
|---|---|
| Synonyms |
1-Azoniabicyclo[2.2.2]octane, 1-[2-(4-fluorophenyl)ethyl]-3-[(2S)-1-oxo-2-phenyl-2-(1-piperidinyl)propoxy]-, (3R)-
(3R)-1-[2-(4-Fluorophenyl)ethyl]-3-{[(2S)-2-phenyl-2-(1-piperidinyl)propanoyl]oxy}-1-azoniabicyclo[2.2.2]octane |
| Description | A novel highly potent, selective, long acting muscarinic receptor M3 antagonist with pIC50 of 9.8, 10-fold selectivity over M2 (pIC50=9.0); demonstrates potential as a treatment for COPD. COPD Phase 2 Discontinued |
|---|---|
| References | References 1. Mete A, et al. Bioorg Med Chem Lett. 2013 Dec 1;23(23):6248-53. 2. Bjermer L, et al. Respir Med. 2013 Jan;107(1):84-90. 3. Mastrodicasa MA, et al. Expert Opin Investig Drugs. 2017 Feb;26(2):161-174. View Related Products by Target mAChR COPD |
| Molecular Formula | C29H38FN2O2+ |
|---|---|
| Molecular Weight | 465.622 |
| Exact Mass | 465.291168 |
| LogP | 2.49 |