1031195-19-3

1031195-19-3 structure

Name: E1231
Chemical Name: 1-(4-{[2-(5-Methyl-2-furyl)-4-quinolinyl]carbonyl}-1-piperazinyl)ethanone
CAS Number: 1031195-19-3
Molecular Formula: C₂₁H₂₁N₃O₃
Molecular Weight: 363.410
Catalog: Signaling Pathways Cell Cycle/DNA Damage Sirtuin
Create Date: 2020-01-11 20:22:46
Modify Date: 2024-10-11 15:48:26
E1231 (E-1231) is a small molecule SIRT1 activator with EC50 of 0.83 uM, interactes with recombinant human SIRT1 protein and deacetylated liver X receptor-alpha (LXRα); increases ATP-binding cassette transporter A1 (ABCA1) expression in RAW 264.7 cells dependent on SIRT1 and LXRα, promotes cholesterol efflux and inhibited lipid accumulation in RAW 264.7 cells via SIRT1 and ABCA1; decreases total cholesterol and triglyceride levels in both serum and the liver in golden hamster hyperlipidemia models.

Name	1-(4-{[2-(5-Methyl-2-furyl)-4-quinolinyl]carbonyl}-1-piperazinyl)ethanone
Synonyms	MFCD10627184 1-(4-{[2-(5-Methyl-2-furyl)-4-quinolinyl]carbonyl}-1-piperazinyl)ethanone Ethanone, 1-[4-[[2-(5-methyl-2-furanyl)-4-quinolinyl]carbonyl]-1-piperazinyl]-

Description	E1231 (E-1231) is a small molecule SIRT1 activator with EC50 of 0.83 uM, interactes with recombinant human SIRT1 protein and deacetylated liver X receptor-alpha (LXRα); increases ATP-binding cassette transporter A1 (ABCA1) expression in RAW 264.7 cells dependent on SIRT1 and LXRα, promotes cholesterol efflux and inhibited lipid accumulation in RAW 264.7 cells via SIRT1 and ABCA1; decreases total cholesterol and triglyceride levels in both serum and the liver in golden hamster hyperlipidemia models.
References	References 1. Feng T, et al. Atherosclerosis. 2018 Jul;274:172-181. View Related Products by Target Sirtuin