1104662-66-9
1104662-66-9 structure
- Name: SNT-207858 free base
- Chemical Name: SNT-207858 free base
- CAS Number: 1104662-66-9
- Molecular Formula: C32H43Cl2N5O3
- Molecular Weight: 616.62
- Catalog: Research Areas Cancer
- Create Date: 2019-12-09 10:28:19
- Modify Date: 2024-01-11 09:30:31
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SNT207858 free base is a selective, blood brain barrier penetrating, potent and orally active melanocortin-4 (MC-4) receptor antagonist. SNT207858 free base has an IC50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor[1].
| Name | SNT-207858 free base |
|---|
| Description | SNT207858 free base is a selective, blood brain barrier penetrating, potent and orally active melanocortin-4 (MC-4) receptor antagonist. SNT207858 free base has an IC50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor[1]. |
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| Related Catalog | |
| Target |
MC-4 receptor[1] |
| In Vitro | SNT207858 binds to the MC-4 receptor with an affinity of 22 nM and shows a 170-fold selectivity vs. MC-3 and a 40-fold selectivity vs. MC-5[1]. |
| In Vivo | SNT207858 (30 mg/kg; oral administration; once daily; 15 days) significantly reduces the tumor induced weight loss in mice[1]. Animal Model: Mice with C26 adenocarcinoma-induced cachexia model[1] Dosage: 30 mg/kg Administration: Oral administration; once daily; 15 days Result: Significantly reduced the tumor induced weight loss. |
| References |
| Molecular Formula | C32H43Cl2N5O3 |
|---|---|
| Molecular Weight | 616.62 |