1104662-66-9

1104662-66-9 structure

Name: SNT-207858 free base
Chemical Name: SNT-207858 free base
CAS Number: 1104662-66-9
Molecular Formula: C₃₂H₄₃Cl₂N₅O₃
Molecular Weight: 616.62
Catalog: Research Areas Cancer
Create Date: 2019-12-09 10:28:19
Modify Date: 2025-08-25 19:53:39
SNT207858 free base is a selective, blood brain barrier penetrating, potent and orally active melanocortin-4 (MC-4) receptor antagonist. SNT207858 free base has an IC50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor[1].

Name	SNT-207858 free base

Description	SNT207858 free base is a selective, blood brain barrier penetrating, potent and orally active melanocortin-4 (MC-4) receptor antagonist. SNT207858 free base has an IC50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Endocrinology
Target	MC-4 receptor[1]
In Vitro	SNT207858 binds to the MC-4 receptor with an affinity of 22 nM and shows a 170-fold selectivity vs. MC-3 and a 40-fold selectivity vs. MC-5[1].
In Vivo	SNT207858 (30 mg/kg; oral administration; once daily; 15 days) significantly reduces the tumor induced weight loss in mice[1]. Animal Model: Mice with C26 adenocarcinoma-induced cachexia model[1] Dosage: 30 mg/kg Administration: Oral administration; once daily; 15 days Result: Significantly reduced the tumor induced weight loss.
References	[1]. Weyermann P, et al. Orally available selective melanocortin-4 receptor antagonists stimulate food intake and reduce cancer-induced cachexia in mice. PLoS One. 2009;4(3):e4774.

Molecular Formula	C₃₂H₄₃Cl₂N₅O₃
Molecular Weight	616.62