2368900-32-5

2368900-32-5 structure

Name: CMLD012073
Chemical Name: CMLD012073
CAS Number: 2368900-32-5
Molecular Formula: C₃₀H₃₀N₂O₇
Molecular Weight: 530.57
Catalog: Signaling Pathways Cell Cycle/DNA Damage Eukaryotic Initiation Factor (eIF)
Create Date: 2019-12-08 15:56:19
Modify Date: 2023-01-14 19:50:12
CMLD012073 is an amidino-rocaglates and is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. CMLD012073 against NIH/3T3 cells with an IC50 of 10 nM. CMLD012073 inhibits eukaryotic translation initiation by modifying the behavior of the RNA helicase (eIF4A)[1].

Name	CMLD012073

Description	CMLD012073 is an amidino-rocaglates and is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. CMLD012073 against NIH/3T3 cells with an IC50 of 10 nM. CMLD012073 inhibits eukaryotic translation initiation by modifying the behavior of the RNA helicase (eIF4A)[1].
Related Catalog	Research Areas >> Cancer
Target	eIF4A[1]
In Vitro	In in vitro translation assays, CMLD012073 is potent at inhibiting cap-dependent translation (FF). In ribosome recruitment experiments, CMLD012073 inhibits assembly of the 80S ribosome on the mRNA[1].
References	[1]. Chu J, et al. Amidino-Rocaglates: A Potent Class of eIF4A Inhibitors. Cell Chem Biol. 2019 Nov 21;26(11):1586-1593.

Molecular Formula	C₃₀H₃₀N₂O₇
Molecular Weight	530.57