1358488-78-4

1358488-78-4 structure

Name: BRD5529
Chemical Name: BRD5529
CAS Number: 1358488-78-4
Molecular Formula: C₂₅H₃₁N₅O₄
Molecular Weight: 465.54
Catalog: Signaling Pathways Others Others
Create Date: 2019-12-08 00:33:54
Modify Date: 2025-08-25 19:42:19
BRD5529 is a selective CARD9-E3 ubiquitin ligase TRIM62 protein-protein interaction inhibitor with an IC50 of 8.6 μM. BRD5529 directly and selectively binds CARD9, disrupts TRIM62 recruitment, inhibits TRIM62-mediated ubiquitinylation and activation of CARD9, and demonstrates cellular activity and selectivity in CARD9-dependent pathways[1].

Name	BRD5529

Description	BRD5529 is a selective CARD9-E3 ubiquitin ligase TRIM62 protein-protein interaction inhibitor with an IC50 of 8.6 μM. BRD5529 directly and selectively binds CARD9, disrupts TRIM62 recruitment, inhibits TRIM62-mediated ubiquitinylation and activation of CARD9, and demonstrates cellular activity and selectivity in CARD9-dependent pathways[1].
Related Catalog	Signaling Pathways >> Others >> Others
Target	IC50: 8.6 μM (CARD9-E3 ubiquitin ligase TRIM62)[1]
References	[1]. Leshchiner ES, et al. Small-molecule inhibitors directly target CARD9 and mimic its protective variant in inflammatorybowel disease. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11392-11397.

Molecular Formula	C₂₅H₃₁N₅O₄
Molecular Weight	465.54