1887055-63-1

1887055-63-1 structure

Name: Salicortin
Chemical Name: Salicortin
CAS Number: 1887055-63-1
Molecular Formula: C₂₀H₂₄O₁₀
Molecular Weight: 424.40
Catalog: Signaling Pathways MAPK/ERK Pathway JNK
Create Date: 2019-12-07 22:06:54
Modify Date: 2024-01-02 18:55:39
Salicortin, a phenolic glycoside, has been isolated from many plants such as Populus and Salix species. Salicortin inhibits osteoclast differentiation and bone resorption by down-regulating JNK and NF-κB/NFATc1 signaling pathways. Salicortin has anti-amnesic, anti-adipogenic, and immune-modulatory activity[1].

Name	Salicortin
Synonyms	MFCD32202744

Description	Salicortin, a phenolic glycoside, has been isolated from many plants such as Populus and Salix species. Salicortin inhibits osteoclast differentiation and bone resorption by down-regulating JNK and NF-κB/NFATc1 signaling pathways. Salicortin has anti-amnesic, anti-adipogenic, and immune-modulatory activity[1].
Related Catalog	Signaling Pathways >> MAPK/ERK Pathway >> JNK
Target	JNK NF-κB
In Vitro	Salicortin (100 μM; 2 hours) almost completely retards the phosphorylation of IκBα[1]. Western Blot Analysis[1] Cell Line: Mouse bone marrow macrophage (BMM) Concentration: 100 μM Incubation Time: 2 hours Result: Retarded the phosphorylation of IκBα.
References	[1]. Nie S, et al. Salicortin inhibits osteoclast differentiation and bone resorption by down-regulating JNK and NF-κB/NFATc1 signaling pathways. Biochem Biophys Res Commun. 2016 Jan 29;470(1):61-67.