874484-20-5
874484-20-5 structure
- Name: S29434
- Chemical Name: S29434
- CAS Number: 874484-20-5
- Molecular Formula: C21H18N4O3
- Molecular Weight: 374.39
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2019-12-08 18:02:19
- Modify Date: 2025-08-25 09:32:07
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S29434 (NMDPEF) is a potent, competitive, selective and cell-permeable inhibitor of quinone reductase 2 (QR2), with IC50s ranging from 5 to 16 nM for human QR2 at different organizational levels, and has good selectivity for QR2 over QR1. S29434 (NMDPEF) induces autophagy and inhibits QR2-mediated ROS production[1].
| Name | S29434 |
|---|
| Description | S29434 (NMDPEF) is a potent, competitive, selective and cell-permeable inhibitor of quinone reductase 2 (QR2), with IC50s ranging from 5 to 16 nM for human QR2 at different organizational levels, and has good selectivity for QR2 over QR1. S29434 (NMDPEF) induces autophagy and inhibits QR2-mediated ROS production[1]. |
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| Related Catalog | |
| Target |
IC50: 5 nM (h QR2, expressed in E. coli, NRH as co-substrate), 16 nM (h QR2, expressed in E. coli, with BNAH as co-substrate)[1] |
| References |
| Molecular Formula | C21H18N4O3 |
|---|---|
| Molecular Weight | 374.39 |