178961-24-5
178961-24-5 structure
- Name: 264W94
- Chemical Name: 264W94
- CAS Number: 178961-24-5
- Molecular Formula: C23H31NO4S
- Molecular Weight: 417.56
- Catalog: Signaling Pathways Others Others
- Create Date: 2019-12-08 09:21:54
- Modify Date: 2025-09-18 18:57:52
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264W94 is a potent ileal bile acid transporter (IBAT) inhibitor and a new cholesterol lowering agent. 264W94 has CYP7A1 induction, and antilipemic action[1].
| Name | 264W94 |
|---|
| Description | 264W94 is a potent ileal bile acid transporter (IBAT) inhibitor and a new cholesterol lowering agent. 264W94 has CYP7A1 induction, and antilipemic action[1]. |
|---|---|
| Related Catalog | |
| Target |
IBAT[1] |
| In Vitro | 264W94 (0, 0.1, 0.25, 0.5 μM) inhibits human IBAT-specific transport of 5 μM TC by 14% to 75% in a concentration-dependent manner with IC50 of 0.25 μM in CHO-hIBAT cells[1]. |
| In Vivo | 264W94 (orally; 0.03-1.0 mg/kg; twice a day for 3.5 days) dose-dependently attenuates diet-induced increases in serum LDL+VLDL-C, as well as the decrease in HDL-C[1]. 264W94 (orally; 0.003, 0.01, 0.03, 0.1 mg/kg; twice a day for 2 days) increases fecal excretion of 75SeHCAT in a dose-dependent manner[1]. 264W94 (0.001, 0.01, 0.1, 1, and 10 mg/kg; twice a day for 2 weeks) reduces dose-dependently plasma glucose in male ZDF (ZDF/GmiCrl-fa/fa) rats. Treatment of 264W94 prevents the decline of insulin dose-dependently without an increase in proinsulin levels[2]. Animal Model: Male Sprague Dawley rats (CD, Charles River, 270-310 gm)[1] Dosage: 0.03, 0.1, 0.3, 1.0 mg/kg Administration: Orally; twice a day (9:00 am and 3:30 pm) for 3.5 days Result: Dose-dependently attenuated diet-induced increases in serum LDL+VLDL-C, as well as the decrease in HDL-C. |
| References |
| Molecular Formula | C23H31NO4S |
|---|---|
| Molecular Weight | 417.56 |