678158-55-9

678158-55-9 structure

Name: Mcl-1-Puma inhibitor 8
Chemical Name: Mcl1-IN-8
CAS Number: 678158-55-9
Molecular Formula: C₂₂H₂₃N₃O₂S
Molecular Weight: 393.50
Catalog: Signaling Pathways Apoptosis Bcl-2 Family
Create Date: 2019-10-07 17:24:05
Modify Date: 2025-08-24 08:09:59
Mcl1-IN-8 (Comp8) is a Mcl-1-PUMA interface inhibitor, with a Ki of 0.3 μM. Mcl1-IN-8 (Comp8) exhibits dual activity on reduce PUMA-dependent apoptosis while deactivating Mcl-1-mediated anti-apoptosis in cancer cells[1].

Name	Mcl1-IN-8

Description	Mcl1-IN-8 (Comp8) is a Mcl-1-PUMA interface inhibitor, with a Ki of 0.3 μM. Mcl1-IN-8 (Comp8) exhibits dual activity on reduce PUMA-dependent apoptosis while deactivating Mcl-1-mediated anti-apoptosis in cancer cells[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Bcl-2 Family Research Areas >> Cancer
Target	Mcl-1:0.3 μM (Ki)
References	[1]. Liu J, et al. Targeting the apoptotic Mcl-1-PUMA interface with a dual-acting compound. Oncotarget. 2017 Apr 20;8(33):54236-54242.

Molecular Formula	C₂₂H₂₃N₃O₂S
Molecular Weight	393.50