1454555-29-3

1454555-29-3 structure

Name: LP-935509
Chemical Name: LP-935509
CAS Number: 1454555-29-3
Molecular Formula: C₂₀H₂₄N₆O₃
Molecular Weight: 396.44
Catalog: Research Areas Neurological Disease
Create Date: 2019-10-08 09:56:52
Modify Date: 2024-01-02 23:23:02
LP-935509 is a small-molecule adapter protein-2 associated kinase 1 (AAK1) selective and brain-penetrantinhibitor (IC50=3.3 nM), a ATP-competitive inhibitor with a Ki of 0.9 nM. LP-935509 is a potent inhibitor of BIKE (IC50=14 nM) and a modest inhibitor of GAK (IC50=320 nM). LP-935509 is highly brain-penetrant and reverses fully established pain behavior following the SNL procedure[1].

Name	LP-935509

Description	LP-935509 is a small-molecule adapter protein-2 associated kinase 1 (AAK1) selective and brain-penetrantinhibitor (IC50=3.3 nM), a ATP-competitive inhibitor with a Ki of 0.9 nM. LP-935509 is a potent inhibitor of BIKE (IC50=14 nM) and a modest inhibitor of GAK (IC50=320 nM). LP-935509 is highly brain-penetrant and reverses fully established pain behavior following the SNL procedure[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
Target	IC50: 3.3 nM (AAK1); 14 nM (BIKE); 320 nM (GAK)[1]
References	[1]. Kostich W, et al. Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain. J Pharmacol Exp Ther. 2016 Sep;358(3):371-86.

Molecular Formula	C₂₀H₂₄N₆O₃
Molecular Weight	396.44