1847485-91-9

1847485-91-9 structure

Name: Ilorasertib hydrochloride
Chemical Name: Ilorasertib hydrochloride
CAS Number: 1847485-91-9
Molecular Formula: C₂₅H₂₂ClFN₆O₂S
Molecular Weight: 525.00
Catalog: Signaling Pathways Cell Cycle/DNA Damage Aurora Kinase
Create Date: 2019-10-08 17:36:18
Modify Date: 2024-01-09 18:52:27
Ilorasertib hydrochloride (ABT-348 hydrochloride) is a potent and ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A with IC50s of 1 nM, 7 nM, 120 nM, respectively. Ilorasertib hydrochloride (ABT-348 hydrochloride) also suppresses RET tyrosine kinase, PDGFRβ and Flt1 with IC50s of 7 nM, 3 nM and 32 nM, respectively[1].

Name	Ilorasertib hydrochloride

Description	Ilorasertib hydrochloride (ABT-348 hydrochloride) is a potent and ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A with IC50s of 1 nM, 7 nM, 120 nM, respectively. Ilorasertib hydrochloride (ABT-348 hydrochloride) also suppresses RET tyrosine kinase, PDGFRβ and Flt1 with IC50s of 7 nM, 3 nM and 32 nM, respectively[1].
Related Catalog	Signaling Pathways >> Epigenetics >> Aurora Kinase Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Aurora Kinase Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PDGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR
Target	Aurora C:1 nM (IC50) Aurora B:7 nM (IC50) Aurora B (Y156H):12 nM (IC50) Aurora A:120 nM (IC50) PDGFRα:11 nM (IC50) PDGFRβ:13 nM (IC50) VEGFR1:1 nM (IC50) VEGFR2:2 nM (IC50) VEGFR3:43 nM (IC50) FLT3:1 nM (IC50) CSF-1R:3 nM (IC50) c-KIT:20 nM (IC50)
References	[1]. Glaser KB, et al. Preclinical characterization of ABT-348, a kinase inhibitor targeting the aurora, vascular endothelial growth factor receptor/platelet-derived growth factor receptor, and Src kinase families. J Pharmacol Exp Ther. 2012 Dec;343(3):617-27.

Molecular Formula	C₂₅H₂₂ClFN₆O₂S
Molecular Weight	525.00