2244035-16-1

2244035-16-1 structure

Name: G907
Chemical Name: G907
CAS Number: 2244035-16-1
Molecular Formula: C₂₆H₂₄ClNO₃
Molecular Weight: 433.93
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2019-10-08 15:08:52
Modify Date: 2024-01-19 15:35:03
G907 is a selective small-molecule antagonist of ATP-binding cassette (ABC) transporter, MsbA. It inhibits purified E. coli MsbA in amphipols with an IC50 of 18 nM. G907 traps MsbA in an inward-facing, lipopolysaccharide-bound conformation by wedging into an architecturally conserved transmembrane pocket. Bactericidal activity[1].

Name	G907

Description	G907 is a selective small-molecule antagonist of ATP-binding cassette (ABC) transporter, MsbA. It inhibits purified E. coli MsbA in amphipols with an IC50 of 18 nM. G907 traps MsbA in an inward-facing, lipopolysaccharide-bound conformation by wedging into an architecturally conserved transmembrane pocket. Bactericidal activity[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
Target	IC50: 18 nM (ABC transporter)[1]
References	[1]. Ho H, et al. Structural basis for dual-mode inhibition of the ABC transporter MsbA. Nature. 2018 May;557(7704):196-201.

Molecular Formula	C₂₆H₂₄ClNO₃
Molecular Weight	433.93