2253744-54-4

2253744-54-4 structure

Name: Dooku 1
Chemical Name: Dooku1
CAS Number: 2253744-54-4
Molecular Formula: C₁₃H₉Cl₂N₃OS
Molecular Weight: 326.20
Catalog: Research Areas Cardiovascular Disease
Create Date: 2019-10-07 19:30:52
Modify Date: 2025-08-25 17:44:36
Dooku1, an analog of Yoda1, is a selective antagonist of the endogenous Piezo1 channel. Dooku1 inhibited 2 μM Yoda1-induced Ca2+-entry with IC50 values of 1.3 μM (in HEK 293 cells) and 1.5 μM (in HUVECs). Dooku1 inhibits Yoda1-induced relaxation of aorta[1].

Name	Dooku1
Synonyms	MFCD32174346

Description	Dooku1, an analog of Yoda1, is a selective antagonist of the endogenous Piezo1 channel. Dooku1 inhibited 2 μM Yoda1-induced Ca2+-entry with IC50 values of 1.3 μM (in HEK 293 cells) and 1.5 μM (in HUVECs). Dooku1 inhibits Yoda1-induced relaxation of aorta[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others
References	[1]. Evans EL, et al. Yoda1 analogue (Dooku1) which antagonizes Yoda1-evoked activation of Piezo1 and aortic relaxation. Br J Pharmacol. 2018 May;175(10):1744-1759.

Molecular Formula	C₁₃H₉Cl₂N₃OS
Molecular Weight	326.20

Hazard Codes	Xi