1846605-04-6
1846605-04-6 structure
- Name: CL2A
- Chemical Name: CL2A
- CAS Number: 1846605-04-6
- Molecular Formula: C51H79N9O18
- Molecular Weight: 1106.22
- Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
- Create Date: 2019-10-09 17:22:29
- Modify Date: 2024-01-21 14:19:31
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CL2A is a complicated PEG8- and triazole-containing PABC-peptide-mc linker. CL2A is cleavable through pH sensitivity, giving rise to bystander effect, and binds the antibody at a cysteine residue via a disulfide bond. Labetuzumab govitecan used this linker[1].
| Name | CL2A |
|---|
| Description | CL2A is a complicated PEG8- and triazole-containing PABC-peptide-mc linker. CL2A is cleavable through pH sensitivity, giving rise to bystander effect, and binds the antibody at a cysteine residue via a disulfide bond. Labetuzumab govitecan used this linker[1]. |
|---|---|
| Related Catalog | |
| Target |
Alkyl/ether |
| References |
[1]. Samantha Congreve, et al. Antibody drug conjugates (ADC). Teknisk- naturvetenskaplig fakultet |
| Molecular Formula | C51H79N9O18 |
|---|---|
| Molecular Weight | 1106.22 |