708991-09-7

708991-09-7 structure

Name: YUKA1
Chemical Name: YUKA1
CAS Number: 708991-09-7
Molecular Formula: C₁₃H₁₆N₄O₂S
Molecular Weight: 292.36
Catalog: Signaling Pathways Epigenetics Histone Demethylase
Create Date: 2019-09-07 18:29:16
Modify Date: 2024-01-10 18:33:21
YUKA1 is a potent and cell permeable Lysine demethylase 5A (KDM5A) inhibitor, with an IC50 of 2.66 μM, less active on KDM5C (IC50, 7.12 μM), and is inactive on KDM5B, KDM6A or KDM6B. YUKA1 increases H3K4me3 levels in human cells with anti-cancer activity[1].

Name	YUKA1

Description	YUKA1 is a potent and cell permeable Lysine demethylase 5A (KDM5A) inhibitor, with an IC50 of 2.66 μM, less active on KDM5C (IC50, 7.12 μM), and is inactive on KDM5B, KDM6A or KDM6B. YUKA1 increases H3K4me3 levels in human cells with anti-cancer activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Histone Demethylase
Target	IC50: 2.66 μM (KDM5A), 7.12 μM (KDM5C)[1]
References	[1]. Gale M, et al. Screen-identified selective inhibitor of lysine demethylase 5A blocks cancer cell growth and drug resistance. Oncotarget. 2016 Jun 28;7(26):39931-39944.

Molecular Formula	C₁₃H₁₆N₄O₂S
Molecular Weight	292.36