1228111-63-4

1228111-63-4 structure

Name: PF-04634817
Chemical Name: PF-04634817
CAS Number: 1228111-63-4
Molecular Formula: C₂₅H₃₆F₃N₅O₃
Molecular Weight: 511.58
Catalog: Signaling Pathways GPCR/G Protein CCR
Create Date: 2019-09-07 15:10:19
Modify Date: 2025-08-26 02:00:22
PF-0463481, an oral CCR2/5 dual antagonist, with a favorable ocular safety profile versus intravitreal therapies[1]. PF-0463481 is safe and well-tolerated and being developed for the treatment of diabetic nephropathy[2].

Name	PF-04634817

Description	PF-0463481, an oral CCR2/5 dual antagonist, with a favorable ocular safety profile versus intravitreal therapies[1]. PF-0463481 is safe and well-tolerated and being developed for the treatment of diabetic nephropathy[2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> CCR Signaling Pathways >> Immunology/Inflammation >> CCR Research Areas >> Inflammation/Immunology
Target	CCR2 CCR5
References	[1]. Gale JD, et al. A CCR2/5 Inhibitor, PF-04634817, Is Inferior to Monthly Ranibizumab in the Treatment of Diabetic Macular Edema. Invest Ophthalmol Vis Sci. 2018 May 1;59(6):2659-2669. [2]. Gale JD, et al. Effect of PF-04634817, an Oral CCR2/5 Chemokine Receptor Antagonist, on Albuminuria in Adults with Overt Diabetic Nephropathy. Kidney Int Rep. 2018 Aug 3;3(6):1316-1327.

Molecular Formula	C₂₅H₃₆F₃N₅O₃
Molecular Weight	511.58