848647-56-3

848647-56-3 structure

Name: J-2156
Chemical Name: J-2156
CAS Number: 848647-56-3
Molecular Formula: C₂₄H₂₈N₄O₄S
Molecular Weight: 468.57
Catalog: Signaling Pathways GPCR/G Protein Somatostatin Receptor
Create Date: 2019-09-07 13:45:19
Modify Date: 2024-01-10 19:16:42
J-2156 is a high potent, selective somatostatin receptor type 4 (SST4 receptor) agonist with IC50s of 0.05 nM and 0.07 nM for human and rat SST4 receptors, respectively. The ED50 of J-2156 in rats for the relief of mechanical allodynia and mechanical hyperalgesia in the ipsilateral hindpaws was 3.7 and 8.0 mg/kg, respectively[1].

Name	J-2156

Description	J-2156 is a high potent, selective somatostatin receptor type 4 (SST4 receptor) agonist with IC50s of 0.05 nM and 0.07 nM for human and rat SST4 receptors, respectively. The ED50 of J-2156 in rats for the relief of mechanical allodynia and mechanical hyperalgesia in the ipsilateral hindpaws was 3.7 and 8.0 mg/kg, respectively[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Somatostatin Receptor Research Areas >> Others
Target	IC50: 0.05 nM (human SST4) and 0.07 nM (rat SST4)[1]
In Vivo	J-2156 (1-10 mg/kg; i.p.; for 3 hours) of single bolus doses has anti-allodynic effect on ipsilateral and contralateral in BCIBP-rats[1]. Animal Model: BCIBP-rats[1] Dosage: 1, 3, 10 mg/kg Administration: I.p.; for 3 hours Result: Had anti-allodynic effect on ipsilateral and contralateral in BCIBP-rats.
References	[1]. Shenoy PA, et al. The Somatostatin Receptor-4 Agonist J-2156 Alleviates Mechanical Hypersensitivity in a Rat Model of Breast Cancer Induced Bone Pain. Front Pharmacol. 2018 May 15;9:495.

Molecular Formula	C₂₄H₂₈N₄O₄S
Molecular Weight	468.57