1527475-61-1

1527475-61-1 structure

Name: PFE-360
Chemical Name: PFE-360
CAS Number: 1527475-61-1
Molecular Formula: C₁₆H₁₆N₆O
Molecular Weight: 308.34
Catalog: Signaling Pathways Autophagy LRRK2
Create Date: 2019-08-04 08:42:59
Modify Date: 2024-01-10 16:55:40
PFE-360 is a potent, selective, brain penetrated and orally active leucine-rich repeat kinase 2 (LRRK2) inhibitor with a mean IC50 of 2.3 nM in vivo[1][2].

Name	PFE-360

Description	PFE-360 is a potent, selective, brain penetrated and orally active leucine-rich repeat kinase 2 (LRRK2) inhibitor with a mean IC50 of 2.3 nM in vivo[1][2].
Related Catalog	Signaling Pathways >> Autophagy >> LRRK2 Research Areas >> Neurological Disease
Target	IC50: 2.3 nM (LRRK2 in vivo) [1][2].
References	[1]. Marco A.S. Baptista, et al. LRRK2 Kinase Inhibitors of Different Structural Classes Induce Abnormal Accumulation of Lamellar Bodies in Type II Pneumocytes in Non-Human Primates but are Reversible and Without Pulmonary Functional Consequences. [2]. Andersen MA, et al. Parkinson's disease-like burst firing activity in subthalamic nucleus induced by AAV-α-synuclein is normalized by LRRK2 modulation. Neurobiol Dis. 2018 Aug;116:13-27.