1642333-05-8

1642333-05-8 structure

Name: 22-(tert-Butoxy)-22-oxodocosanoic acid
Chemical Name: 22-(tert-Butoxy)-22-oxodocosanoic acid
CAS Number: 1642333-05-8
Molecular Formula: C₂₆H₅₀O₄
Molecular Weight: 426.673
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
Create Date: 2019-08-04 00:32:58
Modify Date: 2024-01-01 20:52:59
22-(tert-Butoxy)-22-oxodocosanoic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 22-(tert-Butoxy)-22-oxodocosanoic acid is also a alkyl chain-based PROTAC linker that can be used in t

Name	22-(tert-Butoxy)-22-oxodocosanoic acid
Synonyms	22-[(2-Methyl-2-propanyl)oxy]-22-oxodocosanoic acid Docosanedioic acid, mono(1,1-dimethylethyl) ester

Description	22-(tert-Butoxy)-22-oxodocosanoic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 22-(tert-Butoxy)-22-oxodocosanoic acid is also a alkyl chain-based PROTAC linker that can be used in t
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Non-cleavable
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References	[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.