494830-67-0

494830-67-0 structure

Name: N,N'-(Ethane-1,2-diyl)bis(2-(4-(tert-butyl)phenoxy)acetamide)
Chemical Name: NIC3
CAS Number: 494830-67-0
Molecular Formula: C₂₆H₃₆N₂O₄
Molecular Weight: 440.58
Catalog: Research Areas Cancer
Create Date: 2019-06-29 23:49:05
Modify Date: 2024-01-09 16:53:19
NIC3 is a selective nucleus accumbens-associated protein-1 (NAC1) inhibitor, binds to the conserved Leu-90 of NAC1, prevents its homodimerization, and leads to proteasomal NAC1 degradation. Anti-cancer activity[1].

Name	NIC3

Description	NIC3 is a selective nucleus accumbens-associated protein-1 (NAC1) inhibitor, binds to the conserved Leu-90 of NAC1, prevents its homodimerization, and leads to proteasomal NAC1 degradation. Anti-cancer activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
Target	NAC1[1]
References	[1]. Wang X, et al. Identification of a small-molecule compound that inhibits homodimerization of oncogenic NAC1 protein and sensitizes cancer cells to anticancer agents. J Biol Chem. 2019 May 17. pii: jbc.RA119.007664.

Molecular Formula	C₂₆H₃₆N₂O₄
Molecular Weight	440.58