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1597426-53-3

1597426-53-3 structure
1597426-53-3 structure
  • Name: T-448
  • Chemical Name: T-448
  • CAS Number: 1597426-53-3
  • Molecular Formula: C38H44N8O6S2
  • Molecular Weight: 772.94
  • Catalog: Signaling Pathways Epigenetics Histone Demethylase
  • Create Date: 2019-06-01 20:46:34
  • Modify Date: 2024-07-18 18:14:42
  • T-448 is a specific and irreversible inhibitor of lysine-specific demethylase 1 (LSD1, an H3K4 demethylase), with an IC50 of 22 nM. T-448 enhances H3K4 methylation in primary cultured rat neurons[1].

Name T-448
Description T-448 is a specific and irreversible inhibitor of lysine-specific demethylase 1 (LSD1, an H3K4 demethylase), with an IC50 of 22 nM. T-448 enhances H3K4 methylation in primary cultured rat neurons[1].
Related Catalog
Target

IC50: 22 nM (LSD1)[1].

References

[1]. Matsuda S, et al. T-448, a specific inhibitor of LSD1 enzyme activity, improves learning function without causing thrombocytopenia in mice. Neuropsychopharmacology. 2018 Dec 22.

Molecular Formula C38H44N8O6S2
Molecular Weight 772.94