1309198-71-7

1309198-71-7 structure

Name: Ogerin
Chemical Name: Ogerin
CAS Number: 1309198-71-7
Molecular Formula: C₁₇H₁₇N₅O
Molecular Weight: 307.35
Catalog: Research Areas Neurological Disease
Create Date: 2019-06-01 16:16:16
Modify Date: 2025-09-18 16:31:48
Ogerin is a selective GPR68 positive allosteric modulator, with a pEC50 of 6.83. Ogerin shows inverse agonist and antagonist activity (Ki, 220 nM) at A2A receptoor and weak antagonist activity (Ki, 736 nM) at 5-HT2B receptor. Ogerin blocks recall in fear conditioning in mice[1].

Name	Ogerin

Description	Ogerin is a selective GPR68 positive allosteric modulator, with a pEC50 of 6.83. Ogerin shows inverse agonist and antagonist activity (Ki, 220 nM) at A2A receptoor and weak antagonist activity (Ki, 736 nM) at 5-HT2B receptor. Ogerin blocks recall in fear conditioning in mice[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
Target	pEC50: 6.83 (GPR68)[1] Ki: 220 nM (A2A receptoor), 736 nM (5-HT2B receptor)[1]
References	[1]. Huang XP, et al. Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65. Nature. 2015 Nov 26;527(7579):477-83.

RIDADR	NONH for all modes of transport