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  • DC Chemicals Limited
  • China
  • Product Name: ML303
  • Price: ¥Inquiry/100mg
  • Purity: 98.0%
  • Stocking Period: 1 Day
  • Contact: Tony Cao

1638211-04-7

1638211-04-7 structure
1638211-04-7 structure
  • Name: ML303
  • Chemical Name: ML303
  • CAS Number: 1638211-04-7
  • Molecular Formula: C21H16F3N3O2
  • Molecular Weight: 399.37
  • Catalog: Signaling Pathways Anti-infection Influenza Virus
  • Create Date: 2019-06-02 10:39:43
  • Modify Date: 2024-01-31 10:04:21
  • ML303 is a pyrazolopyridine influenza virus nonstructural protein 1 (NS1) antagonist (IC90 = 155 nM), with an EC50 of 0.7 μM for Influenza A virus H1N1[1].

Name ML303
Description ML303 is a pyrazolopyridine influenza virus nonstructural protein 1 (NS1) antagonist (IC90 = 155 nM), with an EC50 of 0.7 μM for Influenza A virus H1N1[1].
Related Catalog
Target

EC50: 0.7 μM (H1N1)[1].

In Vitro ML303 (20 μM, 6 h) treatment restore IFN-β mRNA levels in MDCK cells[1]. Western Blot Analysis[1] Cell Line: MDCK cells infected with A/PR/8/34, at a MOI of 2, for 6 hours. Concentration: 20 μM. Incubation Time: 6 hours. Result: Restored IFN-β mRNA levels in MDCK cells.
References

[1]. Patnaik S, et al. Identification, design and synthesis of novel pyrazolopyridine influenza virus nonstructural protein 1 antagonists. Bioorg Med Chem Lett. 2019 May 1;29(9):1113-1119.

Molecular Formula C21H16F3N3O2
Molecular Weight 399.37
Storage condition -20°C