1690172-25-8

1690172-25-8 structure

Name: I-191
Chemical Name: I-191
CAS Number: 1690172-25-8
Molecular Formula: C₂₃H₂₆FN₅O₂
Molecular Weight: 423.48
Catalog: Signaling Pathways GPCR/G Protein Protease-Activated Receptor (PAR)
Create Date: 2019-06-02 11:37:52
Modify Date: 2024-01-08 15:44:45
I-191 is a protease-activated receptor 2 (PAR-2) signaling pathway inhibitor extracted from patent WO2015048245A1. I-191 inhibits PAR-2 activators such as SLIGKV, Trypsin, and Thrombin with IC50s of 0.0014 μM, 0.0023 μM, 0.32 μM, respectively[1].

Name	I-191

Description	I-191 is a protease-activated receptor 2 (PAR-2) signaling pathway inhibitor extracted from patent WO2015048245A1. I-191 inhibits PAR-2 activators such as SLIGKV, Trypsin, and Thrombin with IC50s of 0.0014 μM, 0.0023 μM, 0.32 μM, respectively[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Protease-Activated Receptor (PAR) Research Areas >> Inflammation/Immunology
Target	IC50: 0.0014 μM (SLIGKV), 0.0023 μM (Trypsin), 0.32 μM (Thrombin)[1]
References	[1]. Luc J. Farmer, et al. Imidazopyridazines useful as inhibitors of the par-2 signaling pathway. WO2015048245A1.

Molecular Formula	C₂₃H₂₆FN₅O₂
Molecular Weight	423.48