1227948-02-8

1227948-02-8 structure

Name: BI-4464
Chemical Name: BI-4464
CAS Number: 1227948-02-8
Molecular Formula: C₂₈H₂₈F₃N₅O₄
Molecular Weight: 555.55
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK FAK
Create Date: 2019-06-01 19:24:46
Modify Date: 2025-08-26 13:57:40
BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM. A PTK2 ligand for PROTAC[1].

Name	BI-4464

Description	BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM. A PTK2 ligand for PROTAC[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FAK
Target	IC50: 17 nM (PTK2/FAK)[1].
References	[1]. Popow J, et al. Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions. J Med Chem. 2019 Mar 14;62(5):2508-2520.