1313403-49-4
1313403-49-4 structure
- Name: 7-BIA
- Chemical Name: 7-BIA
- CAS Number: 1313403-49-4
- Molecular Formula: C15H18O6
- Molecular Weight: 294.30
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphatase
- Create Date: 2019-06-01 16:20:02
- Modify Date: 2024-01-10 13:25:05
-
7-BIA is a receptor-type protein tyrosine phosphatase D (PTPRD) inhibitor with an IC50 of ~1-3 μM[1].
| Name | 7-BIA |
|---|
| Description | 7-BIA is a receptor-type protein tyrosine phosphatase D (PTPRD) inhibitor with an IC50 of ~1-3 μM[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: ~1-3 μM (PTPRD), 40 μM (PTPRS)[1] |
| In Vitro | 7-BIA (7-butoxy illudalic acid analog) inhibits recombinant human PTPRD and recombinant human PTPRS with IC50 values of ~1–3 μM and 40 μM, respectively[1]. |
| In Vivo | 7-BIA (10-20 mg/kg; given i.p.; only once) reduces cocaine self-administration in highly experienced WT mice[1]. Animal Model: WT mice (available cocaine 50 times, 1 mg/kg infusions on FR1 schedule during ≥20 prior sessions)[1] Dosage: 10 mg/kg, 20 mg/kg Administration: Given i.p.; only once Result: Reduced cocaine self-administration in highly experienced WT mice. |
| References |
| Molecular Formula | C15H18O6 |
|---|---|
| Molecular Weight | 294.30 |