685543-66-2

685543-66-2 structure

Name: RR-11a analog
Chemical Name: RR-11a analog
CAS Number: 685543-66-2
Molecular Formula: C₂₂H₂₉N₅O₈
Molecular Weight: 491.49
Catalog: Research Areas Infection
Create Date: 2019-03-30 11:54:34
Modify Date: 2024-02-04 11:33:06
RR-11a analog is a potent and selective inhibitors of asparaginyl endopeptidases (AE) (Legumain), with IC50 values of 4.5 nM, 4.5 nM and 31 nM for AE1 in Trichomonas Vaginalis, AE in Ixodes ricinus and AE in Schistosoma mansoni, respectively[1].

Name	RR-11a analog

Description	RR-11a analog is a potent and selective inhibitors of asparaginyl endopeptidases (AE) (Legumain), with IC50 values of 4.5 nM, 4.5 nM and 31 nM for AE1 in Trichomonas Vaginalis, AE in Ixodes ricinus and AE in Schistosoma mansoni, respectively[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Others >> Others
Target	IC50: 4.5 nM (AE1 in Trichomonas Vaginalis), 4.5 nM (AE in Ixodes ricinus), 31 nM (AE in Schistosoma mansoni)[1].
References	[1]. Götz MG, et al. Aza-peptidyl Michael acceptors. A new class of potent and selective inhibitors of asparaginyl endopeptidases (legumains) from evolutionarily diverse pathogens. J Med Chem. 2008 May 8;51(9):2816-32.