1140844-63-8

1140844-63-8 structure

Name: nor-NOHA acetate
Chemical Name: nor-NOHA acetate
CAS Number: 1140844-63-8
Molecular Formula: C₉H₂₀N₄O₇
Molecular Weight: 296.28
Catalog: Research Areas Cancer
Create Date: 2019-03-30 19:05:33
Modify Date: 2024-01-09 10:00:40
nor-NOHA acetate is a specific and reversible arginase inhibitor, induces apoptosis in ARG2-expressing cells under hypoxia but not normoxia. Anti-leukemic activity, effective in endothelial dysfunction, immunosuppression and metabolism[1].

Name	nor-NOHA acetate

Description	nor-NOHA acetate is a specific and reversible arginase inhibitor, induces apoptosis in ARG2-expressing cells under hypoxia but not normoxia. Anti-leukemic activity, effective in endothelial dysfunction, immunosuppression and metabolism[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease Signaling Pathways >> Immunology/Inflammation >> Arginase
Target	Arginase[1]
References	[1]. Ng KP, et al. The arginase inhibitor Nω-hydroxy-nor-arginine (nor-NOHA) induces apoptosis in leukemic cells specifically under hypoxic conditions but CRISPR/Cas9 excludes arginase 2 (ARG2) as the functional target. PLoS One. 2018 Oct 11;13(10):e0205254.