460330-27-2

460330-27-2 structure

Name: GT 949
Chemical Name: GT 949
CAS Number: 460330-27-2
Molecular Formula: C₃₀H₃₇N₇O₂
Molecular Weight: 527.66
Catalog: Signaling Pathways Membrane Transporter/Ion Channel EAAT2
Create Date: 2019-03-03 11:46:14
Modify Date: 2024-01-12 16:45:59
GT 949 is a selective excitatory amino acid transporter-2 (EAAT2) positive allosteric modulator with an EC50 of 0.26 nM[1].

Name	GT 949

Description	GT 949 is a selective excitatory amino acid transporter-2 (EAAT2) positive allosteric modulator with an EC50 of 0.26 nM[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> EAAT2 Research Areas >> Neurological Disease
Target	EC50: 0.26±0.03 nM (EAAT2)[1]
In Vitro	GT 949 (GT949) enhances glutamate transport with an EC50 of 0.26 ± 0.03 nM. GT 949 also demonstrates selectivity to EAAT2 and has no effect on glutamate activity mediated by EAAT1 or EAAT3[1]. GT 949 is also tested for its effect on glutamate uptake kinetics in EAAT2-transfected cells. GT 949 enhances glutamate transport in a noncompetitive fashion, with increase in Vmax of about 47%[1].
References	[1]. Kortagere S, et al. Identification of Novel Allosteric Modulators of Glutamate Transporter EAAT2. ACS Chem Neurosci. 2018 Mar 21;9(3):522-534.