Top Suppliers:I want be here

1114546-03-0

1114546-03-0 structure
1114546-03-0 structure
  • Name: Androgen receptor modulators 1
  • Chemical Name: Androgen receptor modulators 1
  • CAS Number: 1114546-03-0
  • Molecular Formula: C14H13F3N2O2
  • Molecular Weight: 298.26
  • Catalog: Research Areas Cancer
  • Create Date: 2019-03-03 10:57:17
  • Modify Date: 2024-01-07 06:02:15
  • Androgen receptor modulators 1 is a selective androgen receptor modulator (SARM). Androgen receptor modulators 1 has strong agonistic activities with an EC50 of 4.7 nM[1].

Name Androgen receptor modulators 1
Description Androgen receptor modulators 1 is a selective androgen receptor modulator (SARM). Androgen receptor modulators 1 has strong agonistic activities with an EC50 of 4.7 nM[1].
Related Catalog
Target

EC50: 4.7 nM (SARM)[1]

In Vitro Androgen receptor modulators 1 (Compounds 2f) induces sexual behavior at the minimal dose (0.5 mg/kg/day, qd, po). It could act as androgen agonist on the CNS[1]. Androgen receptor modulators 1 shows good metabolic stabilities with little species difference between rat, dog, mouse, monkey and human[1].
References

[1]. Aikawa K, et al. Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs) Part III: Discovery of 4-(5-oxopyrrolidine-1-yl)benzonitrile derivative 2f as a clinical candidate. Bioorg Med Chem. 2017 Jul 1;25(13):3330-3349.

Molecular Formula C14H13F3N2O2
Molecular Weight 298.26