1446113-23-0
1446113-23-0 structure
- Name: Belvarafenib
- Chemical Name: Belvarafenib
- CAS Number: 1446113-23-0
- Molecular Formula: C23H16ClFN6OS
- Molecular Weight: 478.93
- Catalog: Signaling Pathways MAPK/ERK Pathway Raf
- Create Date: 2019-02-20 08:04:35
- Modify Date: 2024-01-09 17:50:54
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Belvarafenib is a potent and pan RAF (Rapidly Accelerated Fibrosarcoma) inhibitor, with IC50s of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively.
| Name | Belvarafenib |
|---|
| Description | Belvarafenib is a potent and pan RAF (Rapidly Accelerated Fibrosarcoma) inhibitor, with IC50s of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively. |
|---|---|
| Related Catalog | |
| Target |
BRafV600E:7 nM (IC50) CRAF:5 nM (IC50) B-Raf:56 nM (IC50) |
| In Vitro | Belvarafenib (Example 116) is a potent and pan RAF inhibitor with antineoplastic activity. The IC50 values of Belvarafenib are 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively. It also shows high inhibitory activity for FMS, DDR1 and DDR2 kinases, with IC50s of 10 nM, 23 nM and 44 nM, respectively[1]. |
| References |
[1]. WO 2013/100632 A1. |
| Molecular Formula | C23H16ClFN6OS |
|---|---|
| Molecular Weight | 478.93 |
| Hazard Codes | Xn |
|---|