1227067-61-9
1227067-61-9 structure
- Name: AMG-579
- Chemical Name: AMG 579
- CAS Number: 1227067-61-9
- Molecular Formula: C25H23N5O3
- Molecular Weight: 441.48
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphodiesterase (PDE)
- Create Date: 2019-02-08 18:30:18
- Modify Date: 2024-01-28 15:53:24
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AMG 579 is a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A) with an IC50 of 0.1 nM.
| Name | AMG 579 |
|---|
| Description | AMG 579 is a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A) with an IC50 of 0.1 nM. |
|---|---|
| Related Catalog | |
| Target |
IC50: 0.1 nM (Phosphodiesterase 10A)[1] |
| In Vivo | AMG 579 shows statistically significant reduction of PCP induced behavior in rats over the 2 h period. Minimum effective doses for efficacy in PCP-LMA model is determined to be 0.3 mg/kg for AMG 579. In dog, 5 exhibits superior oral bioavailability of 72%[1]. |
| Animal Admin | Rats[1] Adult male Sprague−Dawley rats (250−280 g) are dosed at 0.1, 0.3, 1, and 3 mg/kg PO 1 h prior to administration of PCP. The magnitude of rat locomotor activity is quantified as number of beam breaks over a 2 h period[1]. |
| References |
| Molecular Formula | C25H23N5O3 |
|---|---|
| Molecular Weight | 441.48 |