291778-77-3
291778-77-3 structure
- Name: AE-3763
- Chemical Name: AE-3763
- CAS Number: 291778-77-3
- Molecular Formula: C23H34F3N5O7
- Molecular Weight: 549.54
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Elastase
- Create Date: 2019-02-08 13:46:20
- Modify Date: 2024-01-08 18:03:48
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AE-3763 is a peptide-based human neutrophil elastase inhibitor with an IC50 of 29 nM.
| Name | AE-3763 |
|---|
| Description | AE-3763 is a peptide-based human neutrophil elastase inhibitor with an IC50 of 29 nM. |
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| Related Catalog | |
| Target |
IC50: 29 nM (Human neutrophil elastase)[1] |
| In Vitro | AE-3763 exhibits potent in vitro inhibitory activity against human neutrophil elastase as well as extremely high solubility and stability in water[1]. |
| In Vivo | Edema and leukocytes infiltration into the lung are significantly inhibited by infusion of AE-3763. AE3763 significantly improves survival rate by 24 h in a mouse model of fatal shock associated with multiple organ dysfunction. AE-3763 dose-dependently prevents hemorrhage when given intravenously by infusion (ED50: 0.42 mg/kg/h) or by bolus injection (1.2 mg/kg). With regard to the toxicity of AE-3763 in mice, the results of a preliminary study have shown no overt toxic effect even at the high dose of 300 mg/kg, iv[1]. |
| Animal Admin | Mice[1] D-Galactosamine shock is induced in C3H/HeN mice (6-7 w, 22-25 g). AE-3763 (10 or 100 mg/kg) is administrated intraperitoneally six times at 2 h interval. Control animals receive the vehicle (PBS) instead of AE-3763. Animal’s survival rate is observed up to 24 h after shock induction[1]. |
| References |
| Molecular Formula | C23H34F3N5O7 |
|---|---|
| Molecular Weight | 549.54 |