2170695-14-2
2170695-14-2 structure
- Name: dTRIM24
- Chemical Name: dTRIM24
- CAS Number: 2170695-14-2
- Molecular Formula: C55H68N8O13S2
- Molecular Weight: 1113.3
- Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
- Create Date: 2019-01-20 04:20:22
- Modify Date: 2024-01-05 20:35:24
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dTRIM24 is a selective bifunctional degrader of TRIM24 based on PROTAC.
| Name | dTRIM24 |
|---|
| Description | dTRIM24 is a selective bifunctional degrader of TRIM24 based on PROTAC. |
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| Related Catalog | |
| Target |
TRIM24[2]. |
| In Vitro | dTRIM24 is a degrader of TRIM24 bromodomain. Recruitment of the VHL E3 ubiquitin ligase by dTRIM24 elicits potent and selective degradation of TRIM24. The anti-proliferative consequences of chemical degradation versus inhibition of TRIM24 are assessed. Growth over time is determined for MOLM-13 cells treated with dTRIM24, IACS-9571, VL-269, and eTRIM24. dTRIM24 suppresses growth to a greater extent than does IACS-9571, accompanied by apoptosis measured as enhanced PARP cleavage. In agreement with a sustained proliferative defect observed following dTRIM24 treatment, near-complete degradation of TRIM24 is observed in dTRIM24-treated cells throughout the duration of the experiment[2]. |
| Cell Assay | MOLM-13 cells are seeded at 30,000 cells/well. Growth over time of MOLM-13 cells treated with 5 μM of indicated compounds (e.g., dTRIM24) over 7 d. At endpoints, cells are suspended and mixed with Viacount reagent at 1:3. The mixture is incubated for 5 min, and viable cells are counted on the Guava easycyte flow cytometer. Means from three technical replicates of cell counts are calculated[2]. |
| References |
| Molecular Formula | C55H68N8O13S2 |
|---|---|
| Molecular Weight | 1113.3 |
| Storage condition | 2-8℃ |