1821143-79-6
1821143-79-6 structure
- Name: DMU2105
- Chemical Name: DMU2105
- CAS Number: 1821143-79-6
- Molecular Formula: C18H13NO
- Molecular Weight: 259.3
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Cytochrome P450
- Create Date: 2019-01-20 17:17:17
- Modify Date: 2024-01-08 18:42:08
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DMU2105 is a potent and specific CYP1B1 inhibitor, with IC50s of 10 nM and 742 nM for CYP1B1 and CYP1A1, respectively.
| Name | DMU2105 |
|---|
| Description | DMU2105 is a potent and specific CYP1B1 inhibitor, with IC50s of 10 nM and 742 nM for CYP1B1 and CYP1A1, respectively. |
|---|---|
| Related Catalog | |
| Target |
CYP1B1:10 nM (IC50) CYP1A1:742 nM (IC50) |
| In Vitro | DMU2105 (Compound 7k) shows 74 and 120-fold selectivity for CYP1B1 over CYP1A1 and CYP1A2. In the presence of DMU2105 however, the EC50 goes down to 1 μM indicating that the cells have suffered from toxicity which may have been mediated by CYP1B1 inhibition. Un-transfected cells (HEK293: pcDNA3.1), when treated with cisplatin and DMU2105 (10×IC50) do not show any perceptible decrease of cisplatin EC50 (8.5 μM ± 0.9)[1]. |
| References |
| Molecular Formula | C18H13NO |
|---|---|
| Molecular Weight | 259.3 |
| Storage condition | 2-8℃ |