363571-83-9
363571-83-9 structure
- Name: Kinesore
- Chemical Name: Kinesore
- CAS Number: 363571-83-9
- Molecular Formula: C20H16Br2N4O4
- Molecular Weight: 536.173
- Catalog: Research Areas Others
- Create Date: 2019-01-20 23:23:52
- Modify Date: 2024-02-02 12:01:32
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Kinesore is an inhibitor of the KLC2-SKIP Interaction.
| Name | Kinesore |
|---|---|
| Synonyms |
3,5-Dibromo-N'-{(E)-[2,5-dimethyl-1-(3-nitrophenyl)-1H-pyrrol-3-yl]methylene}-4-hydroxybenzohydrazide
Benzoic acid, 3,5-dibromo-4-hydroxy-, 2-[(1E)-[2,5-dimethyl-1-(3-nitrophenyl)-1H-pyrrol-3-yl]methylene]hydrazide |
| Description | Kinesore is an inhibitor of the KLC2-SKIP Interaction. |
|---|---|
| Related Catalog | |
| Target |
KLC2-SKIP[1]. |
| In Vitro | Remarkably, in kinesore-treated cells, the microtubule network is entirely reorganized into a series of loops and bundles. In addition, the lysosomal compartment accumulates in a juxtanuclear position, where there are relatively few microtubules. At 50 μM kinesore, this phenotype is highly penetrant, with 95±2.4% (n=3, total of 200 cells) of cells exhibiting a reorganized nonradial microtubule network. In titration experiments, in cells treated for 1 h, this phenotype becomes apparent at a concentration of 25 μM kinesore, with relatively little effect at or below concentrations of 12.5 μM. The effect is reversible because a 2-h washout of kinesore from cells treated for 1 h led to the reestablishment of the radial microtubule array. This kinesore-induced reorganization of the microtubule network is observed in a panel of mammalian normal and cancer cell lines. In wild-type cells, 50 μM kinesore induces the remodeling of the microtubule network and the formation of extensive microtubule-rich projections. This phenotype is strongly suppressed in Kif5B knockout cells, confirming that microtubule remodeling induced by kinesore is dependent upon the presence of kinesin-1[1]. |
| Cell Assay | To examine the effect of kinesore in cells, HeLa cells are treated with 50 μM kinesore or vehicle control (0.1% DMSO) for 1 h[1]. |
| References |
| Density | 1.7±0.1 g/cm3 |
|---|---|
| Molecular Formula | C20H16Br2N4O4 |
| Molecular Weight | 536.173 |
| Exact Mass | 533.953796 |
| LogP | 5.49 |
| Index of Refraction | 1.689 |
| Storage condition | 2-8℃ |