1798331-92-6

1798331-92-6 structure

Name	QX77

Description	QX77 is a chaperone-mediated autophagy (CMA) activator.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cancer
Target	CMA[1]
In Vitro	Treatment with CMA activator QX77 rescues Rab11 down-regulation and trafficking deficiency in cystinotic cells. QX77 treatment also increases LAMP2A localization at the lysosomal membrane[1].
Cell Assay	Mouse embryo fibroblasts are preincubated with QX77 or vehicle (DMSO) 48 h before the addition of tert-butyl hydroperoxide. After an overnight incubation, cell viability is determined by a modified version of the MTT assay[1].
References	[1]. Zhang J, et al. Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A. J Biol Chem. 2017 Jun 23;292(25):10328-10346.