1314378-18-1

1314378-18-1 structure

Name: Bis-PEG2-PFP ester
Chemical Name: Bis-PEG2-PFP ester
CAS Number: 1314378-18-1
Molecular Formula: C₂₀H₁₂F₁₀O₆
Molecular Weight: 538.289712
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
Create Date: 2018-06-14 13:48:12
Modify Date: 2024-01-11 19:05:43
Bis-PEG2-PFP ester is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Bis-PEG2-PFP ester is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].

Name	Bis-PEG2-PFP ester
Synonyms	BIS-PEG2-PFP ESTER

Description	Bis-PEG2-PFP ester is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Bis-PEG2-PFP ester is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Non-cleavable PEGs
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References	[1]. Matthew David DOROSKI, et al. Cytotoxic peptides and antibody drug conjugates thereof. WO2013072813A2. [2]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Molecular Formula	C₂₀H₁₂F₁₀O₆
Molecular Weight	538.289712

Hazard Codes	Xi