62982-31-4

62982-31-4 structure

Name	ALLERGEN GAL D 4 (46-61) (CHICKEN)
Synonyms	LYSOZYME C (46-61) (CHICKEN) Allergen Gal d 4 (46-61), chicken

Description	Allergen Gal d 4 (46-61), chicken is a hen egg white lysozyme peptide.
Related Catalog	Signaling Pathways >> Anti-infection >> Bacterial Peptides Research Areas >> Infection
In Vitro	Allergen Gal d 4 (46-61), chicken (HEL(46-61)) contains the immunodominant epitope recognized by mice of the k haplotype. The binding is shown to be specific, with a Kd of approximately 2 uM. The direct binding of a hen egg white lysozyme peptide, Allergen Gal d 4 (46-61), is examined to membrane I-Ak (protein encoded in the A locus of the I region) molecules in the presence of detergent. A number of synthetic peptide derivatives, which do not stimulate our T-cell reactive hybridomas, compete for the binding of Allergen Gal d 4 (46-61) to I-Ak and also inhibit the functional presentation of Allergen Gal d 4 (46-61). Inhibitors include a peptide lacking a tyrosine at position 53 and a peptide corresponding to the autologous lysozyme peptide. Presentation is examined with cells or with supported planar phospholipid membranes bearing only I-Ak and Allergen Gal d 4 (46-61)[1].
References	[1]. Proc Natl Acad Sci U S A. 1986 Jun;83(12):4509-13.

Molecular Formula	C₇₂H₁₁₆N₂₂O₂₉
Molecular Weight	1753.82