5654-86-4

5654-86-4 structure

Name: Cyclo(Pro-Leu)
Chemical Name: 3-Isobutyl-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
CAS Number: 5654-86-4
Molecular Formula: C₁₁H₁₈N₂O₂
Molecular Weight: 210.27
Catalog: Research Areas Cancer
Create Date: 2018-07-07 00:53:19
Modify Date: 2024-01-08 17:14:33
Cyclo(Pro-Leu) (A 65190) is an active metabolite. Cyclo(Pro-Leu) can be isolated from Streptomyces sp. BM8. Cyclo(Pro-Leu) can be used for the research of cancer[1].

Name	3-Isobutyl-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione

Description	Cyclo(Pro-Leu) (A 65190) is an active metabolite. Cyclo(Pro-Leu) can be isolated from Streptomyces sp. BM8. Cyclo(Pro-Leu) can be used for the research of cancer[1].
Related Catalog	Research Areas >> Cancer
Target	Microbial Metabolite
In Vitro	Cyclo(Pro-Leu) (compound 7) (1.23 μg/mL-300 μg/mL; 48 h) has cytotoxic activity for HT-29, MCF-7, A375, K562, and NCM460 cell lines with IC50 values of 101.56 μM, 78.78 μM, 51.13 μM, 21.72 μM and 775.86 μM, respectively[1].
References	[1]. Shengsheng Lu, et al. Secondary Metabolites with Cytotoxic Activities from Streptomyces sp. BM-8 Isolated from the Feces of Equusquagga. Molecules. 2021 Dec 13;26(24):7556.